Metazosin

Metazosin is an antihypertensive α1-adrenergic receptor antagonist.

Synthesis

 * Metazosin synthesis.svg

The amide (3) is formed when piperazine is reacted with 2-methoxypropionylchloride (2). Metazosin is the product when this intermediate is reacted with the substituted quinazoline (4).