Methylprednisolone aceponate

Methylprednisolone aceponate, or methylprednisolone acetate propionate, sold under the brand names Advantan and Avancort, is a glucocorticoid and a corticosteroid ester—specifically the C17α propionate and C21 acetate diester of methylprednisolone.

In Russia and some other countries the drug is available in 4 dosage forms differing in consistency and water content: emulsion (or lotion), cream, ointment and fatty ointment.

Synthesis

 * methylprednisolone [83-43-2] (1)
 * Triethyl orthopropionate [115-80-0] (2)
 * PC13131717 (3)
 * [79512-61-1] (4)