Michael O'Keefe (disambiguation)

Michael O'Keefe (born 1955) is an American film and television actor.

Michael O'Keefe or O'Keeffe may also refer to;


 * Michael A. O'Keefe (born 1942), Australian physicist
 * Michael Kenny O'Keefe (born 1963), American judge on the D.C. Superior Court
 * Michael O'Keeffe (footballer) (born 1990), New Zealand footballer
 * Michael O'Keeffe (chemist) (born 1934), American crystallographer
 * Michael O'Keefe (Tasmanian politician) (1864–1926), Australian politician in Tasmania
 * Michael O'Keefe (Louisiana politician) (1932–2021), American politician in Louisiana
 * Michael O'Keeffe (Queensland politician) (1854–1941), Australian politician in Queensland
 * Michael O'Keeffe (Irish-American grocer) (1866-1931), co-founder and first president of First National Stores