Mirabamide

Mirabamides are sea sponge isolates that inhibit HIV-1 fusion. Variants A to D are known from Siliquariaspongia mirabilis and E throuh H are derived from Stelletta clavosa. Mirabamides have a macrocyclic region closed through an ester bond between the C-terminus and a 𝛽-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid.

Mirabamide G is a fusion of several amino acids: 2,3 diamino butanoic acid, 3-hydroxyleucine, N-methylthreonine, 2,3-dihydroxy-2,6,8-trimethyldeca-(4Z,6E)-dienoic acid, 3-methoxy alanine, β-methoxytyrosine, 3,4-dimethylglutamine.