Miss Universe Puerto Rico 2021

Miss Universe Puerto Rico 2021 was the 65th edition of the Miss Universe Puerto Rico pageant, held on September 30, 2021 at Luis A. Ferré Performing Arts Center in San Juan, Puerto Rico. Estefanía Soto of San Sebastián crowned Michelle Colón of Loíza as her successor at the end of the event. Colón represented Puerto Rico at the Miss Universe 2021 pageant and finished as Top 10.

Preliminary

 * Uma Blasini – Miss Puerto Rico Universe 2007 from Guayanilla
 * Danna Hernández – Miss Universe Puerto Rico 2017 from San Juan
 * Katiria Soto – Journalist
 * Yamil Ureña – Actor
 * Paul Anthony – Hair and makeup artist
 * Margarita Álvarez – Fashion designer
 * Otilio Santiago – Businessman
 * Maximiliano Córdova – Model and banker
 * Eileen Ojeda – Walgreens director of operations

Final

 * Aleyda Ortiz – Nuestra Belleza Latina 2014
 * Ana Rosa Brito – Miss Universe Puerto Rico 1997 from San Juan
 * Anna di Marco – Doctor
 * Frances Estrada – Fashion blogger and influencer
 * Joyce Giraud – Miss Universe Puerto Rico 1998 from Aguas Buenas
 * Juan Casillas – B Media Group president
 * Madison Anderson – Miss Universe Puerto Rico 2019 from Toa Baja
 * Michelle Pérez – Vicepresident of El Vocero
 * Viviana Ortiz – Miss Universe Puerto Rico 2011 from Corozal

Placements
§ – Voted into the Top 6 by viewers

Contestants
Twenty-six contestants competed for the title.