Missouri's 2nd congressional district

Missouri's second congressional district is in the eastern portion of the state, primarily consisting of the suburbs south and west of St. Louis, including Arnold, Town and Country, Wildwood, Chesterfield, and Oakville. The district includes all of Franklin County and portions of St. Louis, St. Charles, and Warren counties. Following redistricting in 2010, the St. Louis Post-Dispatch reported that the district now included more Democratic-leaning voters than it had its 2001–2010 boundaries, but still leaned Republican as a whole. The latest U.S. Census Electorate Profile for the 2nd congressional district estimates there are 581,131 citizens of voting age living in 293,984 households. A primarily suburban district, MO-02 is the wealthiest of Missouri's congressional districts.

Its current representative is Republican Ann Wagner. Wagner faced Democrat Jill Schupp and Libertarian Martin Schulte in the 2020 general election.