Mr. E

Mr. E may refer to:


 * Mister E, a DC Comics character and member of The Trenchcoat Brigade
 * Mister E (Timely Comics), a Timely Comics (now Marvel Comics) character
 * Mr. E (Ninjago), a character in Ninjago
 * Mr. E, a character in the TV series Scooby-Doo! Mystery Incorporated
 * Mark Oliver Everett (b. 1963), American lead vocalist and guitarist for Eels
 * Nathan Ellery, a DC comics character who masterminded the murder of Alec Holland
 * The ring name of professional wrestler Abe Zvonkin while masked
 * "Mr. E,” a song by Red Velvet from the 2018 EP Summer Magic
 * “Mr. E,” Meal, Ready-to-Eat one of the myriad plays on the acronym MRE within the military.