Myospherulosis

Myospherulosis, also known as spherulocytosis, is a foreign body-type granulomatous reaction to lipid-containing material and blood.

It may be seen in various settings including:
 * Fat necrosis.
 * Malignancy, e.g. renal cell carcinoma.
 * Placement of topical tetracycline in a petrolatum base into a surgical site.

The resultant histopathologic pattern is most unusual and initially was mistakenly thought to represent a previously undescribed endosporulating fungus.