N53

N53 may refer to:

Roads

 * N53 road (Ireland), a road in the Republic of Ireland split by the border with Northern Ireland
 * Nebraska Highway 53, in the United States
 * Santiago–Tuguegarao Bypass Road, in the Philippines

Other uses

 * N53 (Long Island bus)
 * BMW N53, an automobile engine
 * HMS Triad (N53), a submarine of the Royal Navy
 * HNOMS Vale, a minelayer of the Royal Norwegian Navy
 * London Buses route N53
 * Stroudsburg–Pocono Airport, in Monroe County, Pennsylvania, United States