NAD+ synthase (glutamine-hydrolysing)

In enzymology, a NAD+ synthase (glutamine-hydrolysing) is an enzyme that catalyzes the chemical reaction


 * ATP + deamido-NAD+ + L -glutamine + H2O $$\rightleftharpoons$$ AMP + diphosphate + NAD+ + L-glutamate. In eukaryotes, this enzyme contains a glutaminase domain related to nitrilase.

The substrates of this enzyme are ATP, deamido-NAD+, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, NAD+, and glutamate

This enzyme participates in glutamate metabolism and nicotinate and nicotinamide metabolism.

Nomenclature
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is deamido-NAD+:L-glutamine amido-ligase (AMP-forming).