NASC

The acronym NASC can refer to:
 * North American Scrabble Championship, now known as the Scrabble Players Championship
 * National Access and Scaffolding Confederation, a national trade body for access and scaffolding in the UK
 * National Association of State Comptrollers
 * National Association of Student Councils, a U.S. student organization
 * National Aeronautics and Space Council
 * Naval Air Systems Command (NAVAIR), the command of the United States Navy which provides material support for naval aircraft and airborne weapons systems
 * Necessary and sufficient condition, in logic and mathematics
 * New Age Standard Comic, the subtitle of Monthly Dragon Age.
 * North American Solar Challenge, a solar car race in the United States and Canada
 * North American Spondylitis Consortium, a genetic project funded through the University of Texas Health Science Centre, Houston
 * North Augusta, South Carolina
 * Nottingham Arabidopsis Stock Centre, the European collection and distribution centre for the model plant Arabidopsis
 * Number Administration and Service Center (NASC)
 * National Airborne Service Corps, agency in Taiwan dealing with emergency-related transportation
 * National Association of Sports Coaches UK sports coach association

It can also refer to:
 * Nasc, an Irish independent, non-governmental migrant rights centre in Ireland, based in Cork