NCOA6

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.

Function
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.

Interactions
NCOA6 has been shown to interact with:


 * ASCL2 and
 * Activating transcription factor 2,
 * Androgen receptor,
 * CREB-binding protein,
 * DNA-PKcs,
 * E2F1,
 * EP300,
 * Estrogen receptor alpha,
 * Estrogen receptor beta,
 * HBXIP,
 * HIST2H3C,
 * HSF1,
 * Ku70,
 * Ku80,
 * Liver X receptor beta,
 * MLL3,
 * RBBP5,
 * Retinoblastoma protein,
 * Retinoic acid receptor alpha,
 * Retinoid X receptor alpha,
 * Src,
 * TGS1,
 * TUBA4A,
 * TUBB,
 * Thyroid hormone receptor alpha,  and
 * Thyroid hormone receptor beta.