NDN (gene)

Necdin is a protein that in humans is encoded by the NDN gene.

Function
This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.

Necdin is used to stimulate growth regulation and DNA-dependent transcription regulation.

Interactions
NDN (gene) has been shown to interact with:


 * E2F1,
 * HNRNPU,
 * IL1A,
 * Low affinity nerve growth factor receptor,
 * NUCB2, and
 * P53