NOL3

Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene.

Nol3 has been shown to be induced in multiple cancer types and acts as a repressor of apoptosis leading to resistance and proliferation. Paradoxically, loss of Nol3 also leads to hematological disruption in mice resulting in a myeloproliferative neoplasm resembling primary myelofibrosis (PMF), and its deletion has also been detected in patient samples of PMF.

Interactions
NOL3 has been shown to interact with SFRS9 and Caspase 8.