Naphthylpiperazine

1-(1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors,  while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors. It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors,   and may bind to 5-HT4 and the SERT as well. In animals it produces effects including hyperphagia,  hyperactivity,  and anxiolysis,   of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor.