Naruto: Shippuden season 21

The twenty-first and penultimate season of the Naruto: Shippuden anime television series is based on Part II of Masashi Kishimoto's Naruto manga series. The season focuses on Naruto Uzumaki, Sasuke Uchiha, Sakura Haruno and Kakashi Hatake attempting to defeat Kaguya Ōtsutsuki after Madara Uchiha's activation of the Infinite Tsukuyomi and his ultimate betrayal by Zetsu, which is revealed to be a part of Kaguya. The season also depicts Naruto and Sasuke's respective reincarnate connection to Indra and Ashura and their destined, unavoidable final fight. The episodes are directed by Hayato Date, and produced by Pierrot and TV Tokyo. The season aired from May to October 2016.

The season would make its English television debut on Adult Swim's Toonami programming block and premiere on October 8, 2023 to March 3, 2024.

The DVD collection was released on January 11, 2017 under the title The Origins of Ninshū: The Two Souls, Indra and Ashura (忍宗の起源～二つの魂インドラ・アシュラ) and April 5 under the title The Chapter of Naruto and Sasuke (ナルトとサスケの章).

The season contains three musical themes, including one opening and two endings. The opening theme song for the season is "Blood Circulator" (ブラッドサーキュレーター) performed by Asian Kung-Fu Generation. The first ending theme song, "Ao no Lullaby" (青のララバイ) performed by Kuroneko Chelsea, is used from episodes 459–466. The second ending theme song, "Pino to Amélie" (ピノとアメリ) performed by Huwie Ishizaki, is used from episodes 467–479.