Neuronal calcium sensor

Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc. All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.

Members of NCS family
KCNIP1, KCNIP2, Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein), KCNIP4
 * Highly evolutionarily conserved
 * NCS1 (Frequenin)
 * VILIP-1 (Visinin-like-protein-1)
 * HPCAL4 (Visinin-like-protein-2)
 * HPCAL1 (Visinin-like-protein-3)
 * hippocalcin
 * neurocalcin
 * recoverin
 * Guanylate cyclase activator proteins (GCAPs)
 * Potassium Channel interacting proteins (KChIPs 1–4), including: