Nicotinate dehydrogenase

In enzymology, a nicotinate dehydrogenase is an enzyme that catalyzes the chemical reaction



nicotinate + H2O + NADP+ $$\rightleftharpoons$$ 6-hydroxynicotinate + NADPH + H+

The 3 substrates of this enzyme are nicotinate, H2O, and NADP+, whereas its 3 products are 6-hydroxynicotinate, NADPH, and H+.

Classification
This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor.

Nomenclature
The systematic name of this enzyme class is nicotinate:NADP+ 6-oxidoreductase (hydroxylating). Other names in common use include nicotinic acid hydroxylase, and nicotinate hydroxylase.

Biological role
This enzyme participates in nicotinate and nicotinamide metabolism. It has 2 cofactors: FAD, and Iron.