Nifurzide

Nifurzide is a nitrofuran derivative and intestinal anti-infectious agent active against Escherichia coli.

Synthesis

 * Nifurzide synthesis.svg

Esterification of 5-nitrothiophene-2-carboxylic acid (1) with ethanol gives the ester (2). Treatment with hydrazine forms its hydrazide (3). Nifurzide is the hydrazone formed between (3) and 5-nitrofuran-2-acrylaldehyde (4).