Nitric-oxide synthase (NAD(P)H-dependent)

Nitric-oxide synthase (NAD(P)H-dependent) (, nitric oxide synthetase, NO synthase) is an enzyme with systematic name L-arginine,NAD(P)H:oxygen oxidoreductase (nitric-oxide-forming). This enzyme catalyses the following chemical reaction


 * 2 L-arginine + 3 NAD(P)H + 3 H+ + 4 O2 $$\rightleftharpoons$$ 2 L-citrulline + 2 nitric oxide + 3 NAD(P)+ + 4 H2O (overall reaction)
 * (1a) 2 L-arginine + 2 NAD(P)H + 2 H+ + 2 O2 $$\rightleftharpoons$$ 2 N-omega-hydroxy-L-arginine + 2 NAD(P)+ + 2 H2O
 * (1b) 2 N-omega-hydroxy-L-arginine + NAD(P)H + H+ + 2 O2 $$\rightleftharpoons$$ 2 L-citrulline + 2 nitric oxide + NAD(P)+ + 2 H2O

Nitric-oxide synthase (NAD(P)H-dependent) binds heme (iron protoporphyrin IX) and tetrahydrobiopterin.