Non-heme iron protein

In biochemistry, non-heme iron proteins describe families of enzymes that utilize iron at the active site but lack heme cofactors. Iron-sulfur proteins, including those that are enzymes, are not included in this definition.

Some non-heme iron proteins contain one Fe at their active sites, others have pairs of Fe centers:
 * Many mono-Fe proteins are alpha-ketoglutarate-dependent hydroxylases.  Major examples are the lipoxygenases, isopenicillin N synthase, protocatechuate 3,4-dioxygenase, deacetoxycephalosporin-C synthase, and aromatic amino acid hydroxylases.


 * Major diiron enzymes include hemerythrin, some ribonucleotide reductases, some methane monooxygenases, purple acid phosphatases, and ferritin.
 * O2+hemerythrin.svg