Nuclear receptor co-repressor 1

The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.

NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the downregulation of gene expression.

Loss of function of this protein significantly increases the strength and power of mouse muscles.

Family
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 2.

Interactions
Nuclear receptor co-repressor 1 has been shown to interact with:


 * Androgen receptor,
 * CHD1,
 * Calcitriol receptor
 * GPS2,
 * Glucocorticoid receptor,
 * HDAC3,
 * HDAC4,
 * HDAC7A,
 * HDAC9,
 * HEY2,
 * Histone deacetylase 5,
 * MAP3K7IP2,
 * MECP2,
 * Peroxisome proliferator-activated receptor alpha,
 * Peroxisome proliferator-activated receptor gamma
 * Promyelocytic leukemia protein,
 * RUNX1T1,
 * Retinoic acid receptor alpha,
 * Retinoic acid receptor gamma,
 * SAP30,
 * TBL1XR1,
 * TBL1X,   and
 * ZBTB33.