Nucleus prepositus

The nucleus prepositus or nucleus prepositus hypoglossi is one of the largest of the three perihypoglossal nuclei. It is situated in the caudal pons and rostral medulla oblongata. It contributes to several aspects of gaze control including the horizontal gaze holding system.

Injury to the NPH results in inability to hold gaze upon a visual target; conjugate eye movement are however unaffected.

It may be conceptually regarded as a vestibular nucleus.

Anatomy
The NPH is situated near the hypoglossal nucleus. It continuous rostrally with the paramedian pontine reticular formation, and caudally with the intercalated nucleus. It is situated medial to the medial vestibular nucleus.

Connections
It is connected to the superior colliculus.

The NPH has reciprocal connections with the serotonergic raphe nuclei (thereby possibly participating in blood pressure regulation).

Afferents
It receives afferents from the frontal eye fields, medial and dorsal vestibular nuclei, paramedian pontine reticular formation, and interstitial nucleus of Cajal.

Efferents
The nuclei project principally to all three cranial nerve nuclei controling extrinsic eye muscles (the oculomotor (CN III), trochlear (CN IV), and abducens (CN VI) nuclei) via the MLF, with additional efferents to the vestibular nuclei, vestibulocerebellum, and thalamus.

Function
The NPH integrates velocity-position information for horizontal eye movements to enable eccentric gaze. Tonic neurons of the NPH (along with those of with the medial vestibular nucleus) are believed to maintain eccentric (i.e. off resting position) direction of gaze, counteracting forces pulling the eye back to its default, resting, straight-forward gazing position after saccades. The NPH is thought to provide information about eye position.