OSB

OSB may refer to:


 * Orlando Solar Bears
 * OSB, Amtrak station code for the Old Saybrook station in Connecticut, United States
 * Oklahoma School for the Blind
 * OneSavings Bank plc, a UK registered bank that operates under the trade name Kent Reliance
 * Open Source Business Alliance, sometimes known as OSB Alliance
 * Operation Smiling Buddha, code name for India's first successful test explosion of a nuclear bomb (1974)
 * Oberstabsbootsmann, the highest non-commissioned officer rank in the German Navy
 * Operation Sovereign Borders, Australian border security operation
 * Oracle Service Bus, a software communication system made by Oracle Inc.
 * Oregon State Bar, public body that regulates the legal profession in Oregon, United States
 * Oriented strand board, an engineered wood
 * Orquestra Sinfônica Brasileira, the Portuguese name of the Brazilian Symphony Orchestra

Christianity

 * Order of Saint Benedict, Catholic monastic order
 * Order of St Benedict (Anglican), Anglican monastic order
 * Order of Saint Benedict (Orthodox), Orthodox monastic order
 * Orthodox Study Bible, Eastern Orthodox Bible in English that includes the Septuagint