Ohio Brush Creek

Ohio Brush Creek is a 59.9 mi tributary of the Ohio River in southern Ohio in the United States. Via the Ohio River, it is part of the watershed of the Mississippi River, draining an area of 435 sqmi. According to the Geographic Names Information System, it has also been known historically as "Brush Creek," "Elk Creek," and "Little Scioto River".

Ohio Brush Creek rises in southeastern Highland County, and flows generally southwardly into Adams County, past the Serpent Mound, to its confluence at the Ohio River, about 4 mi west of Rome.