Otis House

Otis House may refer to:
 * Otis House (Prescott, Arizona), listed on the NRHP in Yavapai County, Arizona
 * First Harrison Gray Otis House, Boston, MA, listed on the NRHP in Massachusetts
 * Second Harrison Gray Otis House, Boston, MA, listed on the NRHP in Massachusetts
 * Third Harrison Gray Otis House, Boston, MA
 * Otis-Wyman House, Somerville, MA, listed on the NRHP in Massachusetts