P22

P22 may refer to:
 * P22 (type foundry), a digital type foundry, Rochester, New York, United States
 * LÉ Aoife (P22), a patrol vessel of the Irish Naval Service
 * Curtiss XP-22 Hawk, an experimental biplane fighter
 * MALTESE PATROL BOAT P22, of the Armed Forces of Malta
 * Mwera language
 * Papyrus 22, a biblical manuscript
 * Salmonella virus P22, a bacteriophage
 * Walther P22, a pistol
 * Norfolk Southern train P22, involved in the 2005 Graniteville train crash, South Carolina, United States
 * P22, a state regional road in Latvia
 * P-22, a mountain lion that resided in Griffith Park, Los Angeles, California, United States