PBU

PBU may refer to:


 * Patriot Bible University, a fundamentalist Christian correspondence school located in Del Norte, Colorado
 * Primitive Baptist Universalist, Christian Universalist church based primarily in the central Appalachian region of the United States
 * Philadelphia Biblical University, an institution of higher learning located in Langhorne, Pennsylvania, now called Cairn University
 * Pass break up, a gridiron football statistic for passes that are tipped or batted incomplete by the defense without an interception