PGC

PGC may refer to:
 * Pennsylvania Game Commission
 * Persian Gulf Cup, Iran's highest association football league
 * PGC (gene)
 * PGC 1000714, a ring galaxy
 * PGC-1α, a protein which is the master regulator of mitochondrial biogenesis
 * Playwrights Guild of Canada
 * Postgraduate Certificate, usually written as PgC
 * Presbyterian Girls' College in Warwick, Australia, now part of Scots PGC College
 * Primordial germ cell
 * Prince George's County, Maryland
 * Principal Galaxies Catalogue
 * Principle of Generic Consistency, see Alan Gewirth
 * Professional Graphics Controller
 * Program chain, which defines the order in which cells, tiles (video, menus, etc.) are played back on a DVD
 * Psychiatric Genomics Consortium, founded 2007 as the Psychiatric Genome Wide Association Consortium
 * Punjab Group of Colleges, Pakistan
 * The University of Pennsylvania Glee Club