PLAT domain

In molecular biology the PLAT domain is a protein domain that is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase, which mediates membrane association.

This domain forms a beta-sandwich composed of two β-sheets of four β-strands each.

Human proteins containing this domain
ALOX12;   ALOX12B;   ALOX12P2; ALOX15;    ALOX15B;   ALOX5;     ALOXE3;    LIPC; LIPG;     LOXHD1;    LPL;       PKD1;      PKD1L1;    PKD1L2;    PKD1L3;    PKDREJ; PNLIP;    PNLIPRP1; PNLIPRP2; PNLIPRP3; RAB6IP1;