PXO

PXO may refer to:


 * Prospective Executive Officer, in Prospective Commanding Officer
 * Professor X the Overseer, a hip-hop musician
 * IATA airport code for Porto Santo Airport
 * Parallax Online, a provider of free services over the internet in FreeSpace 2
 * Public Works Department in List of U.S. Navy acronyms
 * Patient Experience Officer