Panther Creek (Osage Fork Gasconade River tributary)

Panther Creek is a stream in Webster and Laclede counties in the Ozarks of south-central Missouri. It is a tributary of the Osage Fork Gasconade River. The headwaters are at 37.48583°N, -92.82833°W and the confluence with the Osage Fork is at 37.48°N, -92.71222°W.

Panther Creek was named for the panthers which once roamed its course.