Pennsylvania Route 43 (disambiguation)

Pennsylvania Route 43 may refer to:
 * U.S. Route 22 in Pennsylvania, which was signed in some segments as Pennsylvania Route 43 in the 1920s and 1930s.
 * Schuylkill Expressway, which was signed as Pennsylvania Route 43 in the 1950s and 1960s, currently signed as part of Interstate 76.
 * Mon–Fayette Expressway, which currently uses the Pennsylvania Route 43 designation in its non-tolled sections.