Phenylglyoxylate dehydrogenase (acylating)

In enzymology, a phenylglyoxylate dehydrogenase (acylating; ) is an enzyme that catalyzes the chemical reaction


 * phenylglyoxylate + NAD+ + CoA-SH $$\rightleftharpoons$$ benzoyl-S-CoA + CO2 + NADH

The three substrates of this enzyme are phenylglyoxylate, NAD+, and CoA-SH, whereas its 3 products are benzoyl-S-CoA, CO2, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phenylglyoxylate:NAD+ oxidoreductase. It has 3 cofactors: FAD, Thiamin diphosphate, and Iron-sulfur.