Phosphatidylinositol 3-kinase-related kinase

Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks).

Members
The human PIKK family includes six members:

Structure
PIKKs proteins contain the following four domains:


 * 1) N-terminus FRAP-ATM- TRRAP (FAT) domain,
 * 2)  kinase domain (KD; PI3_PI4_kinase),
 * 3) PIKK- regulatory domain (PRD), and
 * 4) C-terminus FAT-C-terminal (FATC) domain