Phosphoenolpyruvate carboxykinase (diphosphate)

Phosphoenolpyruvate carboxykinase (diphosphate)  is an enzyme with systematic name diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming). This enzyme catalyses the following chemical reaction


 * diphosphate + oxaloacetate $$\rightleftharpoons$$ phosphate + phosphoenolpyruvate + CO2

This enzyme also catalyses the reaction:
 * phosphoenolpyruvate + GTP + CO2 $$\rightleftharpoons$$ pyruvate + GDP.

It is transcriptionally upregulated in the liver by glucagon.