Phosphonoacetaldehyde reductase (NADH)

Phosphonoacetaldehyde reductase (NADH) (, PhpC) is an enzyme with systematic name 2-hydroxyethylphosphonate:NAD+ oxidoreductase. This enzyme catalyses the following chemical reaction


 * 2-hydroxyethylphosphonate + NAD+ $$\rightleftharpoons$$ phosphonoacetaldehyde + NADH + H+

The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate.