Phosphopantothenoylcysteine decarboxylase

The enzyme phosphopantothenoylcysteine decarboxylase catalyzes the chemical reaction


 * N-[(R)-4'-phosphopantothenoyl]-L-cysteine $$\rightleftharpoons$$ pantotheine 4'-phosphate + CO2

This enzyme belongs to the family of lyases, to be specific the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming). This enzyme participates in coenzyme A (CoA) biosynthesis from pantothenic acid.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.