Port Isabel

Port Isabel may refer to:

Places

 * Port Isabel, Texas, USA; a city in Cameron County
 * Port Isabel, Sonora, Mexico; a former port (1864-1879) at the mouth of the Colorado River
 * Port Isabel Independent School District, Cameron County, Texas, USA
 * Port Isabel Slough, Sonora, Mexico; a slough in the Colorado River

Facilities and structures

 * Port Isabel-Cameron County Airport, Texas, USA
 * Port Isabel Air Force Station, Brownsville, Texas, USA
 * Port Isabel Detention Center, Los Fresnos, Texas, USA; a federal ICE detention center
 * Port Isabel High School, Port Isabel, Texas, USA