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Brian's Song is a 1971 ABC Movie of the Week that recounts the details of the life of Brian Piccolo (played by James Caan), a Wake Forest University football player stricken with terminal cancer after turning pro, told through his friendship with Chicago Bears running back teammate and Pro Football Hall of Famer Gale Sayers (Billy Dee Williams), who helps him through the difficult struggle. The production was such a success on ABC television (November 30, 1971) that it was later shown in theaters, Thomas, Bob, with a major premiere in Chicago; however, it was soon withdrawn due to a lack of business. Many critics have called the movie one of, if not the finest telefilm ever made.

The movie is based on Sayers' account of his friendship with Piccolo and coping with Piccolo's illness in Sayers' autobiography, I Am Third. The film was written by veteran screenwriter William Blinn, whose script, one Dallas television critic called, "highly restrained, steering clear of any overt sentimentality [yet conveying] the genuine affection the two men felt so deeply for each other."

Although based on a true story, the film did include some fictional scenes. One example was when George Halas (played by Jack Warden) told Gale Sayers that he wanted to bench Brian Piccolo when he suspected that there may be a problem affecting his performance. He later learned of Brian's cancer. In reality, Jim Dooley was the head coach at that time, as Halas had retired from the position following the 1968 season.

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