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A cardinal-nephew (cardinalis nepos; valido de su tío; prince de fortune) is a cardinal elevated by a pope who is that cardinal's uncle, or more generally, his relative. The practice of creating cardinal-nephews originated in the Middle Ages, and reached its apex during the 16th and 17th centuries Pope Boniface IX, the second pope of the Western Schism, did not appoint cardinal-nephews. Until Pope Innocent XII, the only other exceptions were: Pope Innocent XI (who attempted to abolish the practice), popes who did not appoint cardinals (Pope Pius III, Pope Marcellus II, Pope Urban VII, Pope Leo XI), and Pope Adrian VI (who appointed one cardinal).The institution of the cardinal-nephew evolved over seven centuries, tracking developments in the history of the Papacy and the styles of individual popes. From 1566 until 1692, a cardinal-nephew held the curial office of the Superintendent of the Ecclesiastical State, known as the Cardinal Nephew, and thus the terms are sometimes used interchangeably. The curial office of the Cardinal Nephew as well as the institution of the cardinal-nephew declined as the power of the Cardinal Secretary of State increased and the temporal power of popes decreased in the 17th and 18th centuries.

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