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A paradigm shift, a concept identified by the American physicist and philosopher Thomas Kuhn, is a fundamental change in the basic concepts and experimental practices of a scientific discipline. Kuhn contrasts paradigm shifts, which characterize a scientific revolution, to the activity of normal science, which he describes as scientific work done within a prevailing framework (or paradigm). In this context, the word "paradigm" is used in its original Greek meaning, as "example".

The nature of scientific revolutions has been studied by modern philosophy since Immanuel Kant used the phrase in the preface to the second edition of his Critique of Pure Reason (1787). Kant used the phrase "revolution of the way of thinking" (Revolution der Denkart) to refer to Greek mathematics and Newtonian physics. In the 20th century, new developments in the basic concepts of mathematics, physics, and biology revitalized interest in the question among scholars.

Kuhn presented his notion of a paradigm shift in his influential book The Structure of Scientific Revolutions (1962). Even though Kuhn restricted the use of the term to the natural sciences, the concept of a paradigm shift has also been used in numerous non-scientific contexts to describe a profound change in a fundamental model or perception of events.