Potosi Mine

Potosi Mine may refer to:
 * Cerro Rico, near Potosí, Bolivia, famous for providing vast quantities of silver for Spain during the period of the New World Spanish Empire
 * Potosi Mining District in southern Nevada, U.S., named after Potosí, Bolivia
 * San Luis Potosí, a Mexican state, well known for its gold and silver mines, also named after Potosí, Bolivia