Precorrin-2 dehydrogenase

In enzymology, a precorrin-2 dehydrogenase is an enzyme that catalyzes the chemical reaction


 * precorrin-2 + NAD+ $$\rightleftharpoons$$ sirohydrochlorin + NADH + H+

The two substrates of this enzyme are precorrin-2 and NAD+; its three products are sirohydrochlorin, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is precorrin-2:NAD+ oxidoreductase. Other names in common use include Met8p, SirC, and CysG. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in anaerobic bacteria and to Cofactor F430.