Pregnanetriolone

Pregnanetriolone, or 11-ketopregnanetriol, is a steroid hormone.

Clinical significance
There is no or little urinare excretion of pregnanetriolone in the urine in healthy people.

Pregnanetriolone is a metabolite of 21-deoxycortisol.

In patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH), the daily excretion exceeds 100 μg. ACTH stimulation increased excrement even further. It has been concluded since at least 1974 that the excretion of pregnenolone in urine after ACTH stimulation test can help detect heterozygous carriers of congenital adrenal hyperplasia caused by 21-hydroxylase deficiency (non-classical forms of CAH). These conclusions were confirmed by later studies.

Pregnanetriolone can be used as a marker screening and for monitoring of treatment in infants with classical forms of CAH.