Premnaspirodiene oxygenase

Premnaspirodiene oxygenase (, HPO, Hyoscymus muticus premnaspirodiene oxygenase) is an enzyme with systematic name (-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase. This enzyme catalyses the following chemical reaction


 * (-)-vetispiradiene + 2 NADPH + 2 H+ + 2 O2 $$\rightleftharpoons$$ solavetivone + 2 NADP+ + 3 H2O (overall reaction)
 * (1a) (-)-vetispiradiene + NADPH + H+ + O2 $$\rightleftharpoons$$ solavetivol + NADP+ + H2O
 * (1b) solavetivol + NADPH + H+ + O2 $$\rightleftharpoons$$ solavetivone + NADP+ + 2 H2O

Premnaspirodiene oxygenase heme-thiolate protein (P-450).