Prentiss High School

Prentiss High School was a high school located in Prentiss, Mississippi, United States. It was a part of the Jefferson Davis County School District. It ceased operations at the end of the 2016–17 school year.

Notable alumni

 * Al Jefferson, basketball player for the Indiana Pacers of the NBA; while at Prentiss High he earned the Mississippi Mr. Basketball award
 * John A. Polk, member of Mississippi State Senate