Primera División de México Apertura 2005

Primera División de México (Mexican First Division) Apertura 2005 was the 2005 edition of the Primera Division de Mexico, crowning Mexico's fall champion in football. The season ran from August to December 2005. San Luis was promoted to the Primera División de México thus, Puebla was relegated to the Primera División A. Toluca won the championship and qualified for the CONCACAF Champions' Cup 2006.

Top goalscorers
Players sorted first by goals scored, then by last name. Only regular season goals listed.

Source: MedioTiempo

Quarterfinals
Monterrey won 7–0 on aggregate.

UANL won 5–4 on aggregate.

Toluca won 1–0 on aggregate.

Pachuca won 4–0 on aggregate.

Semifinals
''2–2 on aggregate. Monterrey advanced for being the higher seeded team.''

Toluca won 2–1 on aggregate.

Final
Toluca won 6–3 on aggregate.