Prospero Colonna (disambiguation)

Prospero Colonna may refer to several members of the Colonna family:
 * Prospero I Colonna (c. 1410–1463), Italian Roman Catholic cardinal
 * Prospero II Colonna (1662–1743), Italian Roman Catholic cardinal
 * Prospero Colonna (condottiero) (1452–1523)
 * Prospero Colonna di Sciarra (1707–1765)
 * Prospero Colonna di Paliano, mayor of Rome in 1899–1904