Protein N-terminal methyltransferase

Protein N-terminal methyltransferase (, NMT1 (gene), METTL11A (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein) methyltransferase. This enzyme catalyses the following chemical reaction


 * (1) 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] $$\rightleftharpoons$$ 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein] (overall reaction)
 * (1a) S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,S)PK-[protein]
 * (1b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-(A,S)PK-[protein] $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-(A,S)PK-[protein]
 * (1c) S-adenosyl-L-methionine + N-terminal-N,N-dimethyl-N-(A,S)PK-serine-[protein] $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]
 * (2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] $$\rightleftharpoons$$ 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein] (overall reaction)
 * (2a) S-adenosyl-L-methionine + N-terminal-PPK-[protein] $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-PPK-[protein]
 * (2b) S-adenosyl-L-methionine + N-terminal-N-methyl-N-PPK-[protein] $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]

This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys.